Disorders

Dis straddles DEFINITION Osteogenisis imperfecta (OI) is ?a r atomic number 18 genetic disorder of collagen tax write-off associated with broad spectrum of musculoskeletal problems, about notably bowing and fractures of the extremities, go across weakness, ligamentous laxity, and spinal anaesthesia deformities.? (Binder, 386). Other collagen-containing extraskeletal tissues, such as the sclerae, the teeth, and the heart valves are too affected to a variable degree. OI has a ? everyday feature of bony fragility associated with high-risk formation of collagen by osteoblasts and fibroblasts.

? (Smith, 1983, 13) This di sease, involving defective development of the connective tissues, is usually the pass on of the autosomal dominant gene, but can also be the end of the autosomal recessive gene. Spontaneous mutations are common and the clinical presentation of the disease remains to be quite broad. (Binder, 386) OI is most commonly referred to as ?brittle bones?, but new(prenominal) names include: fragilitas ossium, hypola...If you want to get a ample essay, order it on our website: BestEssayCheap.com

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